| CAS No.: | 1627580-64-6 |
|---|---|
| Formula: | C101h152n28o22s2 |
| EINECS: | / |
| Type: | Lyophilized Powder |
| Appearance: | Powder |
| Quality: | Pharmaceutical Grade |
| Samples: |
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| Customization: |
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| Product Name | Mots-C |
| CAS | 1627580-64-6 |
| MF | C101h152n28o22s2 |
| EINECS | / |
| Water Solubility | Soluble to 0.70 mg/ml in water |
| storage temp | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Product specification | 10mg |
| form | solid |
| color | white |
Description
MOTS-c is a relatively new peptide of 16 amino acids that promote metabolic balance. It regulates metabolic functions throughout the body. For instance, it turns glucose into usable energy.
The DNA in the cell nucleus encodes most peptides. But, the mitochondria's DNA encodes MOTS-c making it unique among peptides.
Research by the University of Southern California found this peptide may help fight weight gain and normalize metabolism - similar to effects mostly linked with exercise.
In mouse studies, the peptide aided glucose metabolism, even when the mice ate a high-fat diet.
These initial studies could indicate improved blood sugar control for those with obesity and type 2 diabetes.
Truthfully, the best MOTS-C dose for enhanced fat loss and better endurance is still up in the air.
here's various protocols that have been suggested by some of the top peptide experts in the world:
Ben Greenfield in his book Boundless: 10 mg of MOTS-C injected once a week, ideally right before endurance exercise for the added mitochondrial benefit, can be repeated for up to 10 weeks in a row every year
Dr. William Seeds in his book Peptide Protocols, Volume 1: 5 mg of MOTS-C injected subcutaneously 3 times per week on a Monday-Wednesday-Friday schedule for 4-6 weeks, followed by a once-a-week dose of 5 mg for 4 weeks.
Dr. Rob Kominiarek: 10 mg of MOTS-C injected subcutaneously into the abdomen once a week for 4 weeks straight, followed by a second 4-week cycle within a 12 month
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Upstream peptide synthesis
Zhaobo Bio production plants are endowed with state-of-the-art equipment for solvent supply, peptide synthesis, purification and isolation of active ingredients and intermediates. All equipment and containment is GMP qualified and cleaning validated. Overlapping capacities and sizes of different equipment trains facilitate a smooth scale-up for increases in demand within the product life cycle.
Downstream purification and isolation of peptides
Zhaobo Bio is committed to the systematic expansion and modernization of its purification equipment in order to ensure the efficient production of ever-increasing amounts of bulk peptide pharmaceuticals.
It uses sophisticated methods for large scale purification campaigns such as preparative high performance liquid chromatography (HPLC), ion exchange (IEX), size-exclusion chromatography (SEC), and ultra-filtration (UF/TFF). The equipment in place permits highly efficient or even continuous manufacturing of extremely pure products up to multi-kg quantities per lot.
For preparative HPLC, dynamic axial compression (DAC) stainless steel columns of up to 60 cm diameter both in batch and continuous mode are packed with the appropriate high performance silica separation phase. For low-pressure chromatography columns up to 80 cm diameter are available. Solvent delivery is ensured from eluent tank farms and containers.
The control of microbiological contamination is a prerequisite for API manufacturing. Class D (ISO 8) and C (ISO 7) clean rooms are supplied via HEPA-filtered, temperature and humidity controlled air, down-flow booths are used for minimizing microbial contamination and protecting operators. Highly active pharmaceutical ingredients are handled in integrated safety workbenches or flexible isolators reaching OEB level 4 (1-10 µg/m3).
Predefined physicochemical properties of the API can only be achieved by a carefully controlled isolation process. Besides precipitation and crystallization, lyophilization of intermediates and final API is a standard unit operation. LaixingPharma have multiple lyophilizers in different sizes (up to 300 liters) located in clean room
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