Customized Thyrotropin-Releasing Hormone, Taltirelin, Human Trh Receptor Lyophilized Powder

• CAS No.: 103300-74-9
• Formula: C17h31n7o9
• EINECS: 103300-74-9
• Type: API
• Appearance: Powder
• Quality: Pharma Grade
• Model NO.: 103300-74-9
• Colour: White
• Peptide Purity: >99.0% HPLC
• Molecular Mass: 477.475
• Bacterial Endotoxins: < 10 EU/Mg
• Total Aerobic Microbial Count: < 10 Cfu/G
• Total Combined Yeasts and Moulds Count: < 10 Cfu/G
• Storage Condition: 2c - 8c, Well-Closed Containers
• Transport Package: Vials/Tray/Tube
• Specification: 10mg 20mg
• Trademark: OEM
• Origin: China
• Production Capacity: 1-5kgs Per Month

Product Description

Taltirelin (TAL) is a thyrotropin-releasing hormone (TRH) analog that is approved for use in humans in Japan. In this study, we characterized TAL binding to and signaling by the human TRH receptor (TRH-R) in a model cell system. We found that TAL exhibited lower binding affinities than TRH and lower signaling potency via the inositol-1,4,5-trisphosphate/calcium pathway than TRH. However, TAL exhibited higher intrinsic efficacy than TRH in stimulating inositol-1,4,5-trisphosphate second messenger generation. This is the first study that elucidates the pharmacology of TAL at TRH-R and shows that TAL is a superagonist at TRH-R. We suggest the superagonism exhibited by TAL may in part explain its higher activity in mediating central nervous system effects in humans compared to TRH.
Taltirelin is primarily being researched for the treatment of spinocerebellar ataxia; limited research has also been carried out with regard to other neurodegenerative disorders, e.g., spinal muscular atrophy

 

Items	Specifications
Business Type	We are a manufacturer of GMP peptide and provide OEM service. The lid also can be customized
Filling amount	The filling amount is 2-5mg extra per bottle.
Purity	The purity is above 99%
Price	Competitive price
Delivery time	The delivery time is stable and short. If you pay before 12 a.m,the goods can be shipped on the same day.
Shipping risk	If the package was lost we will resend the goods to you,so you won't suffer a loss if you buy it.

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Company Profile

Zhaobo Bio acquired early mastery of development and manufacturing of peptides, the short chain amino acids linked by peptide bonds that have enabled new generations of small molecule drugs that closely mimic the body's natural pathways.
Now Zhaobo Bio possesses first-class capabilities to manufacture peptides at industrial scale and in full compliance with the strictest Good Manufacturing Practice (GMP) standards.

Upstream peptide synthesis
Zhaobo Bio production plants are endowed with state-of-the-art equipment for solvent supply, peptide synthesis, purification and isolation of active ingredients and intermediates. All equipment and containment is GMP qualified and cleaning validated. Overlapping capacities and sizes of different equipment trains facilitate a smooth scale-up for increases in demand within the product life cycle. 

Downstream purification and isolation of peptides
Zhaobo Bio is committed to the systematic expansion and modernization of its purification equipment in order to ensure the efficient production of ever-increasing amounts of bulk peptide pharmaceuticals.
It uses sophisticated methods for large scale purification campaigns such as preparative high performance liquid chromatography (HPLC), ion exchange (IEX), size-exclusion chromatography (SEC), and ultra-filtration (UF/TFF). The equipment in place permits highly efficient or even continuous manufacturing of extremely pure products up to multi-kg quantities per lot.
For preparative HPLC, dynamic axial compression (DAC) stainless steel columns of up to 60 cm diameter both in batch and continuous mode are packed with the appropriate high performance silica separation phase. For low-pressure chromatography columns up to 80 cm diameter are available. Solvent delivery is ensured from eluent tank farms and containers.
The control of microbiological contamination is a prerequisite for API manufacturing. Class D (ISO 8) and C (ISO 7) clean rooms are supplied via HEPA-filtered, temperature and humidity controlled air, down-flow booths are used for minimizing microbial contamination and protecting operators. Highly active pharmaceutical ingredients are handled in integrated safety workbenches or flexible isolators reaching OEB level 4 (1-10 µg/m3).
Predefined physicochemical properties of the API can only be achieved by a carefully controlled isolation process. Besides precipitation and crystallization, lyophilization of intermediates and final API is a standard unit operation.  LaixingPharma have multiple lyophilizers in different sizes (up to 300 liters) located in clean rooms.

Certifications

 

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