Foxo4 D-Retro-Inverso High Quality 99% Purity Wholesale Price Foxo4-Dri

• Customization: Available
• CAS No.: 2460055-10-9
• Formula: C228h388n86o64
• Model NO.: 2460055-10-9
• Appearance: Powder
• Quality: Pharmaceutical Grade
• Colour: White
• Purity: >99%
• Shipping Time: 48h
• Arrived Time: 7-14days
• Storage: 2ºC- 8ºC, Well-Closed Containers
• Transport Package: Box/Kit/Tube
• Specification: 5mg
• Trademark: GMP
• Origin: China
• Production Capacity: 100000 Vials Per Month

Product Description

The D-retro inverso (DRI)-isoform of FOXO4 is a cell penetrating peptide shown to selectively induce apoptosis of senescent cells thereby reversing effects of aging in mice. Importantly, the TFA salt has been removed.

D-Retro Inverso (DRI)-isoform of FOXO4 is a synthetic peptide that is derived from the FOXO4 protein, a member of the forkhead box O (FOXO) family of transcription factors. The compound is being studied for its potential anti-aging effects. FOXO4 is known to play a role in various cellular processes such as cell growth, differentiation and apoptosis. It is believed that this DRI-isoform may be able to mimic the activity of the natural FOXO4 protein and promote the expression of certain genes associated with longevity and cellular health.

 The D- and L-amino acid structures are switched to create retro inverso peptides (DRI peptides), linear chains of amino acids with a "reversed" sequence. D amino acids are the mirror image of L amino acids found in all proteins. The major potential property of replacing L amino acid with D amino acid is that the protein structure might subsequently be more stable.

Studies suggest preventing the FOXO4 protein from attaching to the p53 protein [ii] is the primary focus of research into the FOXO4-DRI peptide. Researchers speculate cell cycle progression and death are controlled by the p53 protein, an endogenous regulator protein. Research suggests that the FOXO4 protein may prevent the p53 from binding with DNA, and so apoptosis and cell death. Scientists hypothesize this step may be blocked by the FOXO4-DRI peptide, enabling p53 to connect with DNA and promote cell death.

 FOXo4 DRI is a synthetic peptide that has been studied for its potential use in preventing age-related diseases, extending lifespan, and increasing overall health and wellness. Its mechanism of action is related to binding to and inhibiting the activity of the FOXO4 protein, which plays a role in regulating the ageing process. 

Zhaobo Bio acquired early mastery of development and manufacturing of peptides, the short chain amino acids linked by peptide bonds that have enabled new generations of small molecule drugs that closely mimic the body's natural pathways.
Now Zhaobo Bio possesses first-class capabilities to manufacture peptides at industrial scale and in full compliance with the strictest Good Manufacturing Practice (cGMP) standards.Upstream peptide synthesis.

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