| Customization: | Available |
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| CAS No.: | / |
| Formula: | C18h30n4o9 |
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Molecular formula: C18H30N4O9
Molecular weight: 446.45 g/mol
Sequence: Ala-Glu-Asp-Leu
Bronchogen is a research peptide that has gained attention for its potential therapeutic applications in respiratory diseases and lung regeneration. It is a synthetic peptide consisting of a sequence of amino acids that mimic certain natural peptides found in the body. This composition allows Bronchogen to interact with specific receptors or pathways involved in respiratory function and inflammation. The structure of Bronchogen is designed to target and activate specific receptors in the lungs, promoting cellular growth, repair, and regeneration.
By mimicking the action of natural peptides, Bronchogen may help stimulate the production of new lung tissue and improve respiratory function. Research on Bronchogen is primarily conducted in non-human models to explore its potential benefits and mechanisms of action. Although it is not approved for human use, researchers are investigating its effects on various respiratory conditions, such as chronic obstructive pulmonary disease (COPD), asthma, and acute lung injuries.
Bronchogen works by interacting with specific receptors and pathways involved in lung function and inflammation. One key mechanism of action is through its activation of fibroblast receptors (FGFRs). These receptors play a crucial role in tissue regeneration and repair by promoting cell proliferation, migration, and differentiation. When administered in non-human studies, Bronchogen binds to FGFRs on lung cells, triggering a cascade of intracellular signaling events.
This leads to the activation of various downstream pathways that regulate cell growth, survival, and tissue remodeling. Additionally, Bronchogen has been shown to modulate inflammatory responses by reducing the production of pro-inflammatory cytokines. By targeting these specific receptors and pathways, Bronchogen may promote lung regeneration, reduce inflammation-related damage, and improve overall respiratory function. However, further research is needed to fully understand its complex mechanisms of action.
- Promotion of lung regeneration: Bronchogen has been shown to stimulate the growth and differentiation of lung cells, potentially leading to the regeneration of damaged or injured lung tissue.
- Reduction of inflammation: By modulating inflammatory responses, Bronchogen may help decrease inflammation in the lungs, which is a common feature of respiratory diseases.
- Improved respiratory function: Studies have indicated that Bronchogen can enhance overall lung function by increasing oxygen uptake, improving airflow, and reducing airway resistance.
- Protection against oxidative stress: Oxidative stress is known to contribute to lung damage and disease progression. Bronchogen has demonstrated antioxidant properties, which may help protect against oxidative stress-induced injury.
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Upstream peptide synthesis
Zhaobo Bio production plants are endowed with state-of-the-art equipment for solvent supply, peptide synthesis, purification and isolation of active ingredients and intermediates. All equipment and containment is GMP qualified and cleaning validated. Overlapping capacities and sizes of different equipment trains facilitate a smooth scale-up for increases in demand within the product life cycle.
Downstream purification and isolation of peptides
Zhaobo Bio is committed to the systematic expansion and modernization of its purification equipment in order to ensure the efficient production of ever-increasing amounts of bulk peptide pharmaceuticals.
It uses sophisticated methods for large scale purification campaigns such as preparative high performance liquid chromatography (HPLC), ion exchange (IEX), size-exclusion chromatography (SEC), and ultra-filtration (UF/TFF). The equipment in place permits highly efficient or even continuous manufacturing of extremely pure products up to multi-kg quantities per lot.
For preparative HPLC, dynamic axial compression (DAC) stainless steel columns of up to 60 cm diameter both in batch and continuous mode are packed with the appropriate high performance silica separation phase. For low-pressure chromatography columns up to 80 cm diameter are available. Solvent delivery is ensured from eluent tank farms and containers.
The control of microbiological contamination is a prerequisite for API manufacturing. Class D (ISO 8) and C (ISO 7) clean rooms are supplied via HEPA-filtered, temperature and humidity controlled air, down-flow booths are used for minimizing microbial contamination and protecting operators. Highly active pharmaceutical ingredients are handled in integrated safety workbenches or flexible isolators reaching OEB level 4 (1-10 µg/m3).
Predefined physicochemical properties of the API can only be achieved by a carefully controlled isolation process. Besides precipitation and crystallization, lyophilization of intermediates and final API is a standard unit operation. LaixingPharma have multiple lyophilizers in different sizes (up to 300 liters) located in clean room
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