| Customization: | Available |
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| CAS No.: | / |
| Formula: | C15h26n4o8 |
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Amino Acid Sequence: Lys-Glu-Asp (KEO)
Molecular Formula: C1sH2sN4Oa
Molecular Weight: 390.39 g/mol
PubChem CID: 87571363
Synonyms: lysylglutamyl aspartic acid, SCHEMBL3767701, CHEBl:159909
Vesugen is a bioregulator and geroprotective tripeptide. Research has shown it to protect the vascular system from the effects of aging by limiting the development of atherosclerosis and decreasing overall endothelial cell dysfunction. Systems that are sensitive to vascular damage and decline therefore show the most obvious effects from Vesugen administration. These systems include the central nervous system and cardiovascular system. Vesugen appears to play a prominent role in regulating sirtuin 1 protein levels. Sirtuin 1 has important effects on metabolic processes and helps to reduce the effects of aging. Sirtuin 1 is activated as a result of calorie restriction and is therefore thought to be one of the proteins responsible for the profound anti-aging effects associated with calorie restriction.
Our Advantages: High purity, Wholesale price, large stock, Stealth Shipping, 100% Delivery Guarantee
Upstream peptide synthesis
Zhaobo Bio production plants are endowed with state-of-the-art equipment for solvent supply, peptide synthesis, purification and isolation of active ingredients and intermediates. All equipment and containment is GMP qualified and cleaning validated. Overlapping capacities and sizes of different equipment trains facilitate a smooth scale-up for increases in demand within the product life cycle.
Downstream purification and isolation of peptides
Zhaobo Bio is committed to the systematic expansion and modernization of its purification equipment in order to ensure the efficient production of ever-increasing amounts of bulk peptide pharmaceuticals.
It uses sophisticated methods for large scale purification campaigns such as preparative high performance liquid chromatography (HPLC), ion exchange (IEX), size-exclusion chromatography (SEC), and ultra-filtration (UF/TFF). The equipment in place permits highly efficient or even continuous manufacturing of extremely pure products up to multi-kg quantities per lot.
For preparative HPLC, dynamic axial compression (DAC) stainless steel columns of up to 60 cm diameter both in batch and continuous mode are packed with the appropriate high performance silica separation phase. For low-pressure chromatography columns up to 80 cm diameter are available. Solvent delivery is ensured from eluent tank farms and containers.
The control of microbiological contamination is a prerequisite for API manufacturing. Class D (ISO 8) and C (ISO 7) clean rooms are supplied via HEPA-filtered, temperature and humidity controlled air, down-flow booths are used for minimizing microbial contamination and protecting operators. Highly active pharmaceutical ingredients are handled in integrated safety workbenches or flexible isolators reaching OEB level 4 (1-10 µg/m3).
Predefined physicochemical properties of the API can only be achieved by a carefully controlled isolation process. Besides precipitation and crystallization, lyophilization of intermediates and final API is a standard unit operation. LaixingPharma have multiple lyophilizers in different sizes (up to 300 liters) located in clean room
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