Customization: | Available |
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Appearance: | Powder |
Colour: | White |
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PNC-27, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. PNC-27 is an anticancer peptide. PNC-27 can be used in acute myeloid leukemia research.PNC-27 is synthetic peptide designed to specifically target and destroy cancer cells. Therapeutic peptides have the ability to treat an extensive range of diseases and cancers and contain a large number of advantages over proteins or antibodies.
Tests | Specifications | Results | |
Characters | Appearance | White to almost white loose powder | White loose powder |
Solubility | Soluble in water | Complies | |
Identifications | HPLC | The retention time of the major peak in the chromatogram of the test solution corresponds to that in the chromatogram of the Reference Solution, as obtained in the Assay | Complies |
MALDI-MS | 4813.5±1.0 Da | 4812.6 Da | |
Amino acid analysis | Ser: 4.0-6.0 | 4.6 | |
Asp: 1.6-2.4 | 1.6 | ||
Thr: 1.6-2.4 | 1.8 | ||
Pro: 3.2-4.8 | 4.1 | ||
Tyr: 1.6-2.4 | 2.1 | ||
Leu: 1.6-2.4 | 1.9 | ||
Gly: 3.2-4.8 | 4.0 | ||
Glu: 3.2-4.8 | 3.8 | ||
Ala: 3.2-4.8 | 3.9 | ||
Lys: 1.6-2.4 | 1.9 | ||
Ile: 2.4-3.6 | 3.0 | ||
Phe: 1.6-2.4 | 2.2 | ||
Peptide Purity (HPLC) | ≥ 80% | 93.6% | |
Related Substances | Impurities (HPLC) | Any unspecified impurity ≤ 0.10% | 0.06% |
Toal impurities ≤ 0.50% | 0.12% | ||
Oligomer | ≤ 3.0% | 0.27% | |
Water content (KF) | ≤ 8.0% | 4.63% | |
Sodium ion | Report | 1.1% | |
Residual solvents (GC) | Acetonitril-e ≤ 410 ppm | 246 ppm | |
Bacterial Endotoxins | ≤ 10 EU/mg | Complies | |
Microbiology | Total aerobic microbial count | ≤ 100 CFU/g | < 10 CFU/g |
Total combined yeasts and moulds count | ≤ 100 CFU/g | < 10 CFU/g | |
Escherichia coli count | Absent in 1g | Complies | |
Assay | Calculated as C18H14F4N2O4S on dried substance | 98.0% - 102.0% | 99.8% |
Storage condition: | 2°C - 8°C, well-closed containers, protected from light. |
Remarks: | This batch of product COMPLIES with the prescribed standards. |
Analysed on: | 18.09.2023 |
FAQ
1. How to preserve peptides after receiving them?
Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2°C - 8°C. For long-term storage, peptides should be stored in the form of lyophilized powder stored at -20°C or -80°C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.