| Customization: | Available |
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| CAS No.: | / |
| Formula: | C12h19n3o8 |
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Cartalax is a short bioregulatory peptide with widespread systemic impact due to its effects on fibroblasts. It has been shown to benefit skin and other connective tissues as well as the kidneys. Research shows that Cartalax increases cell proliferation rates and beneficially alters the levels of various cytokines and signaling molecules associated with senescence. Overall, it increases cell health and proliferation while decreasing cell death. Cartalax is thought of as an anti-aging peptide, returning older cells to a more youthful state and prolonging overall tissue health.
Cartalax works through multiple mechanisms to support cartilage health and function. The peptides present in Cartalax act on various cellular pathways involved in cartilage regeneration and repair. One of the key mechanisms is the stimulation of collagen synthesis by . These peptides promote the proliferation and differentiation of chondrocytes, the cells responsible for producing collagen in cartilage tissue.
In addition to collagen synthesis, Cartalax also modulates inflammation through its constituents like. This peptide has been shown to inhibit pro-inflammatory cytokines while promoting the release of anti-inflammatory factors. By reducing inflammation within the joint environment, Cartalax can help minimize tissue damage and provide a favorable environment for cartilage repair.
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Upstream peptide synthesis
Zhaobo Bio production plants are endowed with state-of-the-art equipment for solvent supply, peptide synthesis, purification and isolation of active ingredients and intermediates. All equipment and containment is GMP qualified and cleaning validated. Overlapping capacities and sizes of different equipment trains facilitate a smooth scale-up for increases in demand within the product life cycle.
Downstream purification and isolation of peptides
Zhaobo Bio is committed to the systematic expansion and modernization of its purification equipment in order to ensure the efficient production of ever-increasing amounts of bulk peptide pharmaceuticals.
It uses sophisticated methods for large scale purification campaigns such as preparative high performance liquid chromatography (HPLC), ion exchange (IEX), size-exclusion chromatography (SEC), and ultra-filtration (UF/TFF). The equipment in place permits highly efficient or even continuous manufacturing of extremely pure products up to multi-kg quantities per lot.
For preparative HPLC, dynamic axial compression (DAC) stainless steel columns of up to 60 cm diameter both in batch and continuous mode are packed with the appropriate high performance silica separation phase. For low-pressure chromatography columns up to 80 cm diameter are available. Solvent delivery is ensured from eluent tank farms and containers.
The control of microbiological contamination is a prerequisite for API manufacturing. Class D (ISO 8) and C (ISO 7) clean rooms are supplied via HEPA-filtered, temperature and humidity controlled air, down-flow booths are used for minimizing microbial contamination and protecting operators. Highly active pharmaceutical ingredients are handled in integrated safety workbenches or flexible isolators reaching OEB level 4 (1-10 µg/m3).
Predefined physicochemical properties of the API can only be achieved by a carefully controlled isolation process. Besides precipitation and crystallization, lyophilization of intermediates and final API is a standard unit operation. LaixingPharma have multiple lyophilizers in different sizes (up to 300 liters) located in clean room
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