| Customization: | Available |
|---|---|
| CAS No.: | 67727-97-3 |
| Formula: | C18h33n504 |
|
Still deciding? Get samples of $ !
Request Sample
|
Suppliers with verified business licenses
Audited Supplier Audited by an independent third-party inspection agency
KPV is a peptide that is naturally produced in the body. It is found in the hormone alpha-MSH. This relatively newer peptide is an alpha melanocyte-stimulating hormone. The latest research on hormones in this class have shown immunomodulating and anti-inflammatory effects. KPV has many uses with both auto-immune and inflammatory conditions.
This peptide comes as a cream, injectable, and oral capsules. The route of administration depends on what area needs to be targeted. KPV works very well as a topical cream for things such as acne, eczema and psoriasis. In an oral form, it can help with ulcerative colitis, irritable bowel syndrome, and Crohn's disease. The injectable is used for an overall systemic anti-inflammatory effect.
An overwhelming body of clinical evidence suggests that KPV exerts its strong anti-inflammatory properties through various important mechanisms. KPV exerts its anti-inflammatory function inside cells, where it inactivates inflammatory pathways. KPV can enter the cell and interacts directly with inflammatory signaling molecules. It enters the nucleus of the cell and once it's there, it can inhibit the inflammatory substances and molecules. This leads us to the many benefits KPV has on the gut.
KPV can stop the proinflammatory mechanisms in both intestinal epithelial cells and immune cells. It can interact directly with immune cells which can reduce inflammation. KPV significantly decreased inflammation in colitis. It decreases the inflammatory response by inhibiting proinflammatory cytokine (molecule) synthesis and secretion. KPV may help in the case of IBDs through inhibited immune responses.
Taken orally, KPV decreases pro-inflammatory cytokines which can reduce the incidence of colitis.
KPV also has antimicrobial effects against pathogens. Its antimicrobial effects were demonstrated on two major pathogens called S. aureus and C. albicans. In one study, KPV significantly inhibited S. aureus from forming colonies. KPV, with its anti-inflammatory and anti-microbial properties, can be very helpful for combatting these microbes and healing wounds.
Research in wound healing shows KPV can speed wound healing, reduce infection, fight inflammation, and lead to better cosmetic results. These benefits occur at physiologic concentrations which means KPV could help prevent infection in the setting of serious wounds like burns.
KPV is able to reduce the kind of inflammation that leads to a hypertrophic scar (keloid) formation. Administering KPV (a-MSH) in this setting leads to smaller scars and less drastic inflammatory response. Part of the benefit in reducing scar prominence appears to come from its ability to modulate collagen metabolism.
KPV has significant antimicrobial and anti-inflammatory properties especially in those with psoriasis. Psoriasis is a chronic autoimmune condition that causes the rapid build-up of skin cells and is usually treated using hydroco rtisone. In people with psoriasis, KPV has shown to limit symptoms of the condition including itchiness, dryness, redness, peeling, and more. Therefore, KPV could be used for an extended period of time without risking the unwanted complications of long-term steroid therapy.
KPV is a potent anti-inflammatory peptide that can help many conditions. Most of the research involved is targeting the treatment of IBD (irritable bowel disease) where results have been very positive. KPV is shown to be safe when administered orally, subcutaneously and topically. KPV is a naturally derived peptide without any notable side effects. Research has shown that KPV offers a host of benefits that speed wound healing, reduce infection and fight inflammation.
| Items | Specifications |
| Business Type | We are a manufacturer of GMP peptide and provide OEM service. The lid also can be customized |
| Filling amount | The filling amount is 2-5mg extra per bottle. |
| Purity | The purity is above 99% |
| Price | Competitive price |
| Delivery time | The delivery time is stable and short. If you pay before 12 a.m,the goods can be shipped on the same day. |
| Shipping risk | If the package was lost we will resend the goods to you,so you won't suffer a loss if you buy it. |
Zhaobo Bio acquired early mastery of development and manufacturing of peptides, the short chain amino acids linked by peptide bonds that have enabled new generations of small molecule drugs that closely mimic the body's natural pathways.
Now Zhaobo Bio possesses first-class capabilities to manufacture peptides at industrial scale and in full compliance with the strictest Good Manufacturing Practice (GMP) standards.
Upstream peptide synthesis
Zhaobo Bio production plants are endowed with state-of-the-art equipment for solvent supply, peptide synthesis, purification and isolation of active ingredients and intermediates. All equipment and containment is GMP qualified and cleaning validated. Overlapping capacities and sizes of different equipment trains facilitate a smooth scale-up for increases in demand within the product life cycle.
Downstream purification and isolation of peptides
Zhaobo Bio is committed to the systematic expansion and modernization of its purification equipment in order to ensure the efficient production of ever-increasing amounts of bulk peptide pharmaceuticals.
It uses sophisticated methods for large scale purification campaigns such as preparative high performance liquid chromatography (HPLC), ion exchange (IEX), size-exclusion chromatography (SEC), and ultra-filtration (UF/TFF). The equipment in place permits highly efficient or even continuous manufacturing of extremely pure products up to multi-kg quantities per lot.
For preparative HPLC, dynamic axial compression (DAC) stainless steel columns of up to 60 cm diameter both in batch and continuous mode are packed with the appropriate high performance silica separation phase. For low-pressure chromatography columns up to 80 cm diameter are available. Solvent delivery is ensured from eluent tank farms and containers.
The control of microbiological contamination is a prerequisite for API manufacturing. Class D (ISO 8) and C (ISO 7) clean rooms are supplied via HEPA-filtered, temperature and humidity controlled air, down-flow booths are used for minimizing microbial contamination and protecting operators. Highly active pharmaceutical ingredients are handled in integrated safety workbenches or flexible isolators reaching OEB level 4 (1-10 µg/m3).
Predefined physicochemical properties of the API can only be achieved by a carefully controlled isolation process. Besides precipitation and crystallization, lyophilization of intermediates and final API is a standard unit operation. LaixingPharma have multiple lyophilizers in different sizes (up to 300 liters) located in clean rooms.
){kind=link}