Factory Wholse Cognitive Enhancer for Humans Fgl Peptide 499993-62-3

• CAS No.: 499993-62-3
• Formula: C71h116n20o25
• EINECS: 499993-62-3
• Type: API
• Appearance: Powder
• Quality: Pharma Grade
• Model NO.: 499993-62-3
• Colour: White
• Peptide Purity: >99.0% HPLC
• Molecular Mass: 2195.44
• Bacterial Endotoxins: < 10 EU/Mg
• Total Aerobic Microbial Count: < 10 Cfu/G
• Total Combined Yeasts and Moulds Count: < 10 Cfu/G
• Storage Condition: 2c - 8c, Well-Closed Containers
• Transport Package: Vials/Tray/Tube
• Specification: 10mg 20mg
• Trademark: OEM
• Origin: China
• Production Capacity: 1-5kgs Per Month

Product Description

Product Description

What Is FGL Peptide?
Standing for 'Fibroblast Gro wth Loop,' FGL is a small peptide with neurotrophic properties derived from the neural cell adhesion molecule (NCAM). NCAM is a molecule that plays a vital role in neural development and synaptic activities associated with memory and learning. Due to the effects on the NCAM by a mechanism discussed below, FGL can have cognition-enhancing effects.

How Does FGL Peptide Work?
After being administered into the brain, FGL penetrates the blood-brain barrier, which is a barrier between the brain's blood vessels and the cells, then performs its activity in the brain. While the FGL peptide can produce a cascade of effects on the human brain, this article focuses on two primary mechanisms, which involve the NCAM and the synapses.

FGL Peptide and the NCAM
According to a review, NCAM functions by binding to fibroblast grow th factor receptors (FGFRs), which activate neural development pathways. As an FGFRs agonist, FGL mimics the activity of NCAM in binding to the FGFRs. While binding to FGFRs, FGL activates the signaling pathways controlled by the FGFRs. This activation strengthens synaptic connections through a mechanism associated with memory and learning.

FGL Peptide and the Synapses
According to a review, FGL stimulates the activity-dependent delivery of receptors to the synapses, enhancing synaptic transmission. Notably, FGL does not lead to spontaneous enhanced synaptic transmission. Instead, the peptide promotes long-term potentiation (LTP) only in response to synaptic activity. Long-term potentiation in the brain region treated with FGL is almost twice as strong as in the untreated areas.

This activity-dependent quality is essential because if a peptide uncontrollably increases synaptic transmission, it might excessively stimulate the brain, resulting in epilepsy. By enhancing synaptic transmission only in response to synaptic activity, the FGL peptide helps efficiently encode information, resulting in improved memory. This suggests that the FGL peptide may be particularly useful in treating conditions where synaptic transmission is weakened, such as Alzheimer's disease (AD) and depression.

 

Items	Specifications
Business Type	We are a manufacturer of GMP peptide and provide OEM service. The lid also can be customized
Filling amount	The filling amount is 2-5mg extra per bottle.
Purity	The purity is above 99%
Price	Competitive price
Delivery time	The delivery time is stable and short. If you pay before 12 a.m,the goods can be shipped on the same day.
Shipping risk	If the package was lost we will resend the goods to you,so you won't suffer a loss if you buy it.

Detailed Photos

Company Profile

Zhaobo Bio acquired early mastery of development and manufacturing of peptides, the short chain amino acids linked by peptide bonds that have enabled new generations of small molecule drugs that closely mimic the body's natural pathways.
Now Zhaobo Bio possesses first-class capabilities to manufacture peptides at industrial scale and in full compliance with the strictest Good Manufacturing Practice (GMP) standards.

Upstream peptide synthesis
Zhaobo Bio production plants are endowed with state-of-the-art equipment for solvent supply, peptide synthesis, purification and isolation of active ingredients and intermediates. All equipment and containment is GMP qualified and cleaning validated. Overlapping capacities and sizes of different equipment trains facilitate a smooth scale-up for increases in demand within the product life cycle. 

Downstream purification and isolation of peptides
Zhaobo Bio is committed to the systematic expansion and modernization of its purification equipment in order to ensure the efficient production of ever-increasing amounts of bulk peptide pharmaceuticals.
It uses sophisticated methods for large scale purification campaigns such as preparative high performance liquid chromatography (HPLC), ion exchange (IEX), size-exclusion chromatography (SEC), and ultra-filtration (UF/TFF). The equipment in place permits highly efficient or even continuous manufacturing of extremely pure products up to multi-kg quantities per lot.
For preparative HPLC, dynamic axial compression (DAC) stainless steel columns of up to 60 cm diameter both in batch and continuous mode are packed with the appropriate high performance silica separation phase. For low-pressure chromatography columns up to 80 cm diameter are available. Solvent delivery is ensured from eluent tank farms and containers.
The control of microbiological contamination is a prerequisite for API manufacturing. Class D (ISO 8) and C (ISO 7) clean rooms are supplied via HEPA-filtered, temperature and humidity controlled air, down-flow booths are used for minimizing microbial contamination and protecting operators. Highly active pharmaceutical ingredients are handled in integrated safety workbenches or flexible isolators reaching OEB level 4 (1-10 µg/m3).
Predefined physicochemical properties of the API can only be achieved by a carefully controlled isolation process. Besides precipitation and crystallization, lyophilization of intermediates and final API is a standard unit operation.  LaixingPharma have multiple lyophilizers in different sizes (up to 300 liters) located in clean rooms.

Certifications

 

Customers feedback